RFQ - Preparative HPLC

The National Physical Laboratory (NPL) requires automation to facilitate the purification of peptides which have been synthesized via 9-Fluorenylmethoxycarbonyl (Fmoc) Solid Phase Peptide Synthesis (SPPS). Due to the intrinsic nature of this synthetic technique, it is quite common to isolate crude peptides as a mixture of the desired product and closely related impurities (e.g. protecting group adducts / deletion sequences). NPL tends to synthesize difficult peptides (self assembling, repeating motifs, slightly insoluble sequences) on 0.1 mmol scale via microwave assisted Fmoc SPPS; yielding 150 mg to 400 mg of crude product after resin cleavage. NPL is seeking to purchase a preparative …

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