UK SBS RE18378 SEC-MALS System

The MRC Laboratory of Molecular Biology uses size exclusion chromatography (SEC) coupled to multi angle light scattering (MALS) as part of its protein purification, protein characterization, quality control and particle mass / size quantitation, all of which are integral to the laboratory's main research themes in structural biology. The SEC-MALS instrumentation must be able to determine particle size and mass over a wide dynamic range from small peptides and nucleic acid fragments up to large mass protein complexes, detergent vesicles or virus like particles.